Yazar "Beler, Merih" için listeleme
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3-Pyridinylboronic acid ameliorates rotenone-induced oxidative stress through Nrf2 target genes in zebrafish embryos
Üstündağ, Fümet Duygu; Ünal, İsmail; Üstündağ, Ünsal Veli; Cansız, Derya; Beler, Merih; Karagöz, Atakan; Kara Subaşat, Hülya; Alturfan, Ahmet Ata; Mega Tiber, Pınar; Emekli Alturfan, Ebru (Springer, 2022)Parkinson's disease (PD) is one of the most common forms of neurodegenerative diseases and research on potential therapeutic agents for PD continues. Rotenone is a neurotoxin that can pass the blood-brain barrier and is ... -
Alcian blue staining for chondrocranium development in zebrafish
Beler, Merih; Ünal, İsmail; Cansız, Derya; Emekli Alturfan, Ebru (Humana Press Inc., 2024)Craniofacial abnormalities are one of the most frequent birth malformations in humans, affecting around one in every thousand live births. The zebrafish (Danio rerio), a model organism that has seen increased usage in ... -
Assessment of developmental neurotoxicity using semi-automatic behavior analysis system for zebrafish
Cansız, Derya; Ünal, İsmail; Beler, Merih; Alturfan, Ahmet Ata; Emekli Alturfan, Ebru (Humana Press Inc., 2024)Traditionally, morphological, conventional, and toxicological approaches have been used to demonstrate neurotoxicity; however, there has been a growing interest in animal behavioral methods for assessing neurotoxicity, ... -
Bisphenol a reveals its obesogenic effects through disrupting glucose tolerance, oxidant–antioxidant balance, and modulating inflammatory cytokines and fibroblast growth factor in zebrafish
Beler, Merih; Cansız, Derya; Ünal, İsmail; Üstündağ, Ünsal Veli; Dandin, Esra; Ak, Esin; Alturfan, A. Ata; Emekli Alturfan, Ebru (SAGE Publications Ltd, 2022)Obesogens affect lipid metabolism, and genetic or epigenetic factors may also contribute to the progression of obesity. Endocrine-disrupting chemicals (EDCs) are the most striking among obesogens. Bisphenol A (BPA) is an ... -
The effect of acetic acid-induced pain in Parkinson's disease model in zebrafish
Cansız, Derya; Ünal, İsmail; Beler, Merih; Üstündağ, Ünsal Veli; Ak, Esin; Emekli Alturfan, Ebru; Alturfan, Ahmet Ata (Elsevier B.V., 2023)Parkinson's disease (PD) is the second most common neurodegenerative disease caused by the degeneration of dopaminergic neurons and the accumulation of Lewy bodies. Pain is one of the most common non-motor symptoms in PD, ... -
Endotoxin of porphyromonas gingivalis amplifies the inflammatory response in hyperglycemia-induced zebrafish through a mechanism involving chitinase-like protein YKL-40 analogs
Gündüz, Gizem; Beler, Merih; Ünal, İsmail; Cansız, Derya; Emekli Alturfan, Ebru; Köse, Kemal Naci (Springer, 2023)Porphyromonas gingivalis (P. gingivalis), a key pathogen in periodontal diseases, is also associated with hyperglycemia-associated systemic diseases, including diabetes mellitus (DM). Gingipains are the most important ... -
Gingipain injection affects intestinal oxidant-antioxidant status and alkaline phosphatase in overfed zebrafish
Gündüz, Gizem; Beler, Merih; Ünal, İsmail; Cansız, Derya; Emekli Alturfan, Ebru; Köse, Kemal Naci (Istanbul University Press, 2023)Objective: Porphyromonas gingivalis (P. gingivalis), a major periodontopathogen, is associated with overfeeding disorders, including metabolic syndrome. Gingipains are one of the most powerful endotoxins of P. gingivalis. ... -
Identification of molecular network of gut-brain axis associated with neuroprotective effects of PPAR delta-ligand erucic acid in rotenone-induced Parkinson's disease model in zebrafish
Ünal, İsmail; Cansız, Derya; Sürmen, Mustafa Gani; Sürmen, Saime; Sezer, Zehra; Beler, Merih; Üstündağ, Ünsal Veli; Güzel, Elif; Alturfan, Ahmet Ata; Emekli Alturfan, Ebru (Wiley, 2023)Disruption of the gut-brain axis in Parkinson's disease (PD) may lead to motor symptoms and PD pathogenesis. Recently, the neuroprotective potential of different PPAR delta-agonists has been shown. We aimed to reveal the ... -
Microarray analysis to determine gene expression changes in zebrafish embryos
Ünal, İsmail; Beler, Merih; Cansız, Derya; Emekli Alturfan, Ebru (Humana Press Inc., 2024)Chemical exposure in humans begins from the zygote stage and continues throughout the development of the embryo and the fetus. Zebrafish are one of the most powerful model organisms used in many research areas, including ... -
Morphine ameliorates pentylenetetrazole-induced locomotor pattern in zebrafish embryos; mechanism involving regulation of opioid receptors, suppression of oxidative stress, and inflammation in epileptogenesis
Üstündağ, Fümet Duygu; Ünal, İsmail; Üstündağ, Ünsal Veli; Cansız, Derya; Beler, Merih; Alturfan, Ahmet Ata; Tiber, Pınar Mega; Emekli Alturfan, Ebru (Taylor and Francis Ltd., 2023)Zebrafish (Danio rerio) is becoming an increasingly important model in epilepsy research. Pentylenetetrazole (PTZ) is a convulsant agent that induces epileptic seizure-like state in zebrafish and zebrafish embryos and is ... -
Panoramic dental X-ray exposure leads to oxidative stress, inflammation and apoptosis-mediated developmental defects in zebrafish embryos
Karagöz, Atakan; Beler, Merih; Altun, Büşra Dilara; Ünal, İsmail; Cansız, Derya; Gündüz, Hüseyin; Alturfan, Ahmet Ata; Emekli Alturfan, Ebru; Erçalık Yalçınkaya, Şebnem (Elsevier Masson s.r.l., 2023)Panoramic x-ray units are widely used in dental radiodiagnostics. Patients are exposed to relatively low radiation doses with panoramic imaging, but considering lifetime frequency of exposure, even a small risk can have ... -
Quantitative real-time PCR method to evaluate gene expression in zebrafish embryos
Beler, Merih; Cansız, Derya; Ünal, İsmail; Emekli Alturfan, Ebru (Humana Press Inc., 2024)The fast zebrafish embryonic development offers an opportunity for the study of genes crucial for developmental processes. Several genes associated with human diseases have orthologs in zebrafish. Enhanced comprehension ... -
Sodium-dependent glucose co-transporter-2 inhibitor empagliflozin exerts neuroprotective effects in rotenone-induced Parkinson's disease model in zebrafish; mechanism involving ketogenesis and autophagy
Ünal, İsmail; Cansız, Derya; Beler, Merih; Sezer, Zehra; Güzel, Elif; Emekli Alturfan, Ebru (Elsevier B.V., 2023)Sodium-dependent glucose co-transporter-2 (SGLT2) inhibitor empagliflozin (EMP), is the new class of oral hypoglycemic agent approved as a treatment for Type 2 diabetes. SGLT2 inhibitors may induce ketogenesis through ... -
Stevioside ameliorates hyperglycemia and glucose intolerance, in a diet-induced obese zebrafish model, through epigenetic, oxidative stress and inflammatory regulation
Dandin, Esra; Üstündağ, Ünsal Veli; Ünal, İsmail; Ateş Kalkan, Perihan Seda; Cansız, Derya; Beler, Merih; Ak, Esin; Alturfan, A. Ata; Emekli Alturfan, Ebru (Elsevier Ltd, 2022)Obesity is an independent risk factor for type 2 diabetes and epigenetic regulatory mechanisms affect obesityrelated mechanisms. Due to weight gain concern in society, artificial sweeteners with no nutritional value have ... -
Stevioside improves brain oxidant-antioxidant status in overfed zebrafish
Dandin, Esra; Ünal, İsmail; Beler, Merih; Üstündağ, Ünsal Veli; Cansız, Derya; Ateş Kalkan, Perihan Seda; Emekli Alturfan, Ebru (Istanbul University Press, 2023)Objective: An excessive buildup of adipose tissue is a defining feature of overnutrition, and a significant fraction of the world's population suffers from obesity. Overnutrition is associated with the deterioration of ... -
Whole-mount RNA in situ hybridization of zebrafish embryos
Ünal, İsmail; Cansız, Derya; Beler, Merih; Alturfan, Ahmet Ata; Emekli Alturfan, Ebru (Humana Press Inc., 2024)A commonly employed technique in molecular biology to evaluate the temporal and spatial expression of a certain gene is in situ hybridization. This method is an effective strategy to construct synexpression groups, ...